化工社化工社 化学情報印刷レポート · 研究参考用
Cyclopropanecarboxylic acid → N-(1-cyclopropylcarbonylpiperidin-4-yl)-4-fluorobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclopropanecarboxylic acid | HCID 15655 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | 4-fluoro-N-(piperidin-4-yl)benzamide | HCID 4778226 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(1-cyclopropylcarbonylpiperidin-4-yl)-4-fluorobenzamide | HCID 9926015 | — |
反応手順
To a suspension of N-(piperidin-4-yl)-4-fluorobenzamide (556 mg) in dichloromethane (6 ml) were added cyclopropanecarboxylic acid (0.20 ml), 1-hydroxybenzotriazole (338 mg) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (480 mg) at ambient temperature. After stirring for 21 hours, the mixture was diluted with dichloromethane, and washed with water, saturated aqueous sodium hydrogen carbonate, and brine. After drying with magnesium sulfate, the solvents were removed under reduced pressure. After crystallization from diisopropyl ether, N-(1-cyclopropylcarbonylpiperidin-4-yl)-4-fluorobenzamide (627 mg) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06710043B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-172de2d3a4fd4dff8daa387af3ff6796 |
| 出典メモ | uspto-grants-2004_03 |