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Ethyl 2-benzoyl-3-ethoxyacrylate → HCID 178471943、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 2-benzoyl-3-ethoxyacrylate | HCID 98006 | — |
| 反応物 | 6-Ethoxy-2-hydrazinopyridine | HCID 22320339 | — |
| 反応物 | 1-(6-ethoxy-2-pyridinyl)-3-methyl-1H-pyrazol-5-ylamine | HCID 22320358 | — |
| 反応物 | Aminocrotononitrile | HCID 86589747 | — |
| 生成物 | HCID 178471943 | HCID 178471943 | — |
反応手順
Following the procedure described in Reference Example 1-1, 3-methyl-1-(6-ethoxy-2-pyridinyl)-1H-pyrazol-5-amine was prepared from aminocrotononitrile and 6-ethoxy-2-hydrazinopyridine. Following the procedure described in Reference Example 1-2, the compound was subjected to a reaction with ethyl 2-benzoyl-3-ethoxy-2-propenoate to give ethyl 2-benzoyl-3-[[3-methyl-1-(6-ethoxy-2-pyridinyl)-1H-pyrazol-5-yl]amino)-2-propenoate. The compound was treated following the method described in Example 1-4 to give the title compound (35% cyclization yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06949648B2 |
| 出典データセット | uspto-grants-2005_09 |
| ORD ID | ord-09d21879ef4e418a985dbeccb7eb4c1e |
| 出典メモ | uspto-grants-2005_09 |