Ethyl Acetate → HCID 178429193、化合物

HRID 497957ノート

反応式

HRID 497957 の反応式
[CH3:1][C:2]1[CH:6]=[C:5]([NH2:7])[N:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[N:3]=1.[C:14](OCC)(=[O:19])[CH2:15][C:16]([CH3:18])=O.C(OCC)(=O)C>C(O)(=O)C>[CH3:1][C:2]1[C:6]2[C:5](=[N:7][C:14]([OH:19])=[CH:15][C:16]=2[CH3:18])[N:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[N:3]=1

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 8868Ethyl AcetoacetateHCID 7351323-Methyl-1-(pyridin-2-yl)-1H-pyrazol-5-amine

生成物 1

HCID 178429193HCID 178429193、化合物収率 63.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-amine (5.1 g, 29 mmol) and ethyl acetoacetate (3.8 g, 30 mmol) in acetic acid (14 mL) was stirred at 100° C. for 4 hours. The solution was cooled to room temperature and ethyl acetate was added thereto. The resulting crude crystals were collected by filtration, and recrystallized from ethanol to give the title compound (4.4 g, 62% yield).

後処理

  1. filtrationThe resulting crude crystals were collected by filtration
  2. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-7f85c5375b614450a81179d53aaa42b7
出典データセット
uspto-grants-2005_09
特許番号
US06949648B2

反応ノート

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