4-Fluoro-2-nitrobenzoic acid → 4-Fluoroanthranilic acid

HRID 497985

反応式

HRID 497985 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([N+:11]([O-])=O)[CH:3]=1>C(O)C.[C].[Pd]>[NH2:11][C:4]1[CH:3]=[C:2]([F:1])[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

参加物

4

反応物 1

HCID 27374164-Fluoro-2-nitrobenzoic acid

生成物 1

HCID 27249674-Fluoroanthranilic acid収率 100%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

To a solution of 4-fluoro-2-nitrobenzoic acid (22.5 g, 0.1 mol) in ethanol (200 mL), 10% palladium-carbon (1.0 g, 50% hydrate) was added, and the mixture was stirred at room temperature under hydrogen atmosphere for 4 hours. The solution was filtered to remove the catalyst, and the filtrate was concentrated under reduced pressure to give the title compound (8.38 g, 100% yield).

後処理

  1. filtrationThe solution was filtered
  2. customto remove the catalyst
  3. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-99db7bd8acd54b54a0511e335fc39b0d
出典データセット
uspto-grants-2005_09
特許番号
US06949648B2

関連ノート

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