Water → 7-Fluoroisatin

HRID 497987

反応式

HRID 497987 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:13])[CH:10]=NO.[OH2:14]>S(=O)(=O)(O)O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[NH:8][C:9](=[O:13])[C:10]2=[O:14]

参加物

4

反応物 2

HCID 962WaterHCID 6710880N-(2-fluorophenyl)-2-(hydroxyimino)acetamide

生成物 1

HCID 5864187-Fluoroisatin収率 46%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
70 °C

実験手順

A solution of N-(2-fluorophenyl)-2-(hydroxyimino)acetamide (35.0 g, 192 mmol) in sulfuric acid (150 mL) was heated and stirred at 70° C. for 45 minutes. The solution was allowed to cool to room temperature and poured into iced water, and organic matter was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The resulting crystals were collected by filtration to give the title compound (14.6 g, 46% yield).

後処理

  1. temperatureto cool to room temperature
  2. extractionwas extracted with ethyl acetate
  3. washThe extract was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated under reduced pressure
  6. filtrationThe resulting crystals were collected by filtration

出典と根拠

ORDレコード
ord-e546cbf11300420e89834fc0987f4dee
出典データセット
uspto-grants-2005_09
特許番号
US06949648B2

関連ノート

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