Hydrochloric Acid → 3-Methyl-1-(3-pyridinyl)-1H-pyrazol-5-ylamine dihydrochloride

HRID 498057

反応式

HRID 498057 の反応式
N/[C:2](=[CH:5]\[CH3:6])/[C:3]#[N:4].[ClH:7].Cl.[NH:9]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[NH2:10].Cl>O>[ClH:7].[ClH:7].[CH3:6][C:5]1[CH:2]=[C:3]([NH2:4])[N:9]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[N:10]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 171324893-Hydrazinylpyridine dihydrochlorideHCID 86589747Aminocrotononitrile

生成物 1

HCID 574176993-Methyl-1-(3-pyridinyl)-1H-pyrazol-5-ylamine dihydrochloride収率 96.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of aminocrotononitrile (8.21 g, 100 mmol) and 3-hydrazinopyridine dihydrochloride (20.7 g, 114 mmol) in water (50 mL) was mixed with conc. hydrochloric acid (15 mL), and the mixture was heated under reflux for 30 minutes. The solution was allowed to cool to room temperature, and the reaction solvent was evaporated under reduced pressure, and the resulting crystals were collected by filtration. The crystals obtained were washed with water and air dried to give the title compound (13.6 g, 55% yield).

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. customthe reaction solvent was evaporated under reduced pressure
  4. filtrationthe resulting crystals were collected by filtration
  5. customThe crystals obtained
  6. washwere washed with water and air
  7. customdried

出典と根拠

ORDレコード
ord-477c0bb6523b4f85baa2fe527a4edd3e
出典データセット
uspto-grants-2005_09
特許番号
US06949648B2

関連ノート

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