Stannous chloride dihydrate → tert-Butyl (2-amino-4-chloro-5-methylphenyl)carbamate

HRID 498209ノート

反応式

HRID 498209 の反応式
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([Cl:15])=[CH:10][C:9]=1[N+:16]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([Cl:15])=[CH:10][C:9]=1[NH2:16])([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 2

HCID 61436Stannous chloride dihydrateHCID 69489578tert-butyl N-(4-chloro-5-methyl-2-nitrophenyl)carbamate

生成物 1

HCID 69486983tert-Butyl (2-amino-4-chloro-5-methylphenyl)carbamate

実験手順

The title compound was prepared from (4-chloro-5-methyl-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example A17) (4.45 g, 15.5 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as a yellow solid (3.90 g, 98%).

出典と根拠

ORDレコード
ord-ec715028ebe84840b9805c489dc25e6b
出典データセット
uspto-grants-2005_09
特許番号
US06949542B2

反応ノート

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