Stannous chloride dihydrate → (2-Amino-4-chloro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

HRID 498211ノート

反応式

HRID 498211 の反応式
[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[C:11]([Cl:18])=[CH:10][C:9]=1[N+:19]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[C:11]([Cl:18])=[CH:10][C:9]=1[NH2:19])([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 2

HCID 61436Stannous chloride dihydrateHCID 69486643(4-Chloro-2-nitro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

生成物 1

HCID 69487014(2-Amino-4-chloro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

実験手順

The title compound was prepared from (4-chloro-2-nitro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example A19) (3.37 g, 0.99 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as an orange solid (2.55 g, 83%).

出典と根拠

ORDレコード
ord-66f359677600412baa30234145b8a0d9
出典データセット
uspto-grants-2005_09
特許番号
US06949542B2

反応ノート

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