Hydrogen Peroxide → 3-(2-Acetoxymethyl-pyridin-4-yl)-benzoic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH3:16])[CH:11]=2)[CH:5]=1.OO>C(O)(=O)C.C(OC(=O)C)(=O)C>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH2:16][O:17][C:3](=[O:2])[CH3:4])[CH:11]=2)[CH:5]=1参加物
5
実験手順
Oxidation of 3-(2-methyl-pyridin-4-yl)-benzoic acid methyl ester (26.2 g, 0.11 mol; example K12) with H2O2 (30%, 31.5 ml, 0.31 mol) in acetic acid (117 ml) at 70° C. for 27 h and subsequent reaction of the N-oxide in acetic acid anhydride (22 ml) at 135° C. for 30 min yielded after aqueous work-up 3-(2-acetoxymethyl-pyridin-4-yl)-benzoic acid methyl ester (25.3 g, 82%) as a brown oil.
出典と根拠
- ORDレコード
- ord-8d92bc8c26f649549c6afb186889ca2c
- 出典データセット
- uspto-grants-2005_09
- 特許番号
- US06949542B2
反応ノート
読み込み中…