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tert-Butyl (3-amino-2'-fluoro-[1,1'-biphenyl]-4-yl)carbamate → (2'-Fluoro-3-{3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl (3-amino-2'-fluoro-[1,1'-biphenyl]-4-yl)carbamate | HCID 67361423 | — |
| 反応物 | 3-[3-(6-Methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester | HCID 69489386 | — |
| 生成物 | (2'-Fluoro-3-{3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert-butyl ester | HCID 86589228 | — |
反応手順
The title compound was prepared from (3-amino-2′-fluoro-biphenyl-4-yl)-carbamic acid tert-butyl ester [CAS-No. 335255-65-7] (227 mg, 0.75 mmol) and 3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K4) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow solid (347 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06949542B2 |
| 出典データセット | uspto-grants-2005_09 |
| ORD ID | ord-b09b53fb79614b34a3776e4f29e760c6 |
| 出典メモ | uspto-grants-2005_09 |