化工社化工社 化学情報印刷レポート · 研究参考用
Water → 4-(Morpholin-4-yl)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | 4-Morpholinobenzonitrile | HCID 394808 | — |
| 生成物 | 4-(Morpholin-4-yl)benzoic acid | HCID 345278 | 99% |
反応手順
A solution of 4-(4-morpholinyl)benzonitrile (930 mg, 5.00 mmol) in 1:1 dioxane:water (20 mL) was treated with potassium hydroxide (1.12 g, 20 mmol). The mixture was heated at reflux for 96 h, concentrated, and the residue was dissolved in water. Upon acidification (pH ˜2-3), a white precipitate resulted which was collected by filtration yielding 1.21 g (99%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06710057B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-7ad0d7d1880144fa87a13458aa991f81 |
| 出典メモ | uspto-grants-2004_03 |