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3-Oxo-3-(3-pyrazin-2-yl-phenyl)-propionic acid tert-butyl ester → {4-Methyl-2-[3-oxo-3-(3-pyrazin-2-yl-phenyl)-propionylamino]-5-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Oxo-3-(3-pyrazin-2-yl-phenyl)-propionic acid tert-butyl ester | HCID 69489103 | — |
| 反応物 | (2-Amino-4-methyl-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester | HCID 69489396 | — |
| 生成物 | {4-Methyl-2-[3-oxo-3-(3-pyrazin-2-yl-phenyl)-propionylamino]-5-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester | HCID 86589286 | — |
反応手順
The title compound was prepared from (2-amino-4-methyl-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J23) (290 mg, 1.0 mmol) and 3-oxo-3-(3-pyrazin-2-yl-phenyl)-propionic acid tert-butyl ester (Example K14) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as a white foam (290 mg, 56%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06949542B2 |
| 出典データセット | uspto-grants-2005_09 |
| ORD ID | ord-671151f6e7964ad0a93b2f8178c5887c |
| 出典メモ | uspto-grants-2005_09 |