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Hydrochloric Acid → H-Gly-Leu-Ala-OBzl HCl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Trifluoroacetate | HCID 84468 | — |
| 反応物 | H-Leu-Ala-OBzl | HCID 16742166 | — |
| 反応物 | Boc-Gly-Leu-Ala-OBzl | HCID 131717744 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | H-Gly-Leu-Ala-OBzl HCl | HCID 131718105 | — |
反応手順
Boc-Gly-Leu-Ala-OBzl was prepared by coupling Boc-Gly-OH (5.70 g, 32.6 mmoles) to H-Leu-Ala-OBzl using the mixed anhydride procedure described in Example 2. The product (13.8 g) was obtained as an amorphous solid. Boc-Gly-Leu-Ala-OBzl was deblocked with trifluoroacetic acid by the procedure described for the preparation of H-Leu-Ala-OBzl except that the trifluoroacetate salt was soluble in ether. The preparation was dissolved in ethyl acetate and treated with anhydrous hydrogen chloride. The resulting product was precipitated by the addition of ether to yield 7.7 g of H-Gly-Leu-Ala-OBzl HCl in a first crop.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242904 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-1e9e6ea312024abbb5827b12a87dd34a |
| 出典メモ | uspto-grants-1993_09 |