関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Butanol | HCID 263 | — |
| 反応物 | 1-Phenethylamine, (-)- | HCID 75818 | — |
| 反応物 | 1-Chloro-4-(4-pyridinylmethyl)phthalazine | HCID 1944609 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (R)-1-(1-Phenylethylamino)-4-(4-pyridylmethyl)phthalazine dihydrochloride | HCID 69837621 | — |
反応手順
A mixture of 0.511 g (2 mmol) 1-chloro-4-(4-pyridylmethyl)phthalazine, 1.273 ml (10 mmol) (S)-1 phenylethylamine and 5 ml 1-butanol is stirred for 40 h at 110° C. After processing as described in Example 12 and equilibration for 65 hours at 20° C. and in room atmosphere, title compound is obtained with a water content of 10.53%; m.p. 190° C. (decomp.); ESI-MS: (M+H)+=341; [α]D20=+38.4±0.70 (c=1.507%, methanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06710047B2 |
|---|
| 出典データセット | uspto-grants-2004_03 |
|---|
| ORD ID | ord-0e3f3997fada4ff0972d23f85223536c |
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| 出典メモ | uspto-grants-2004_03 |
|---|
