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3-Chloroaniline → 7-Acetamino-1-(3-chloroanilino)-4-(4-pyridylmethyl)phthalazine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chloroaniline | HCID 7932 | — |
| 反応物 | 7-Acetamino-1-chloro-4-(4-pyridylmethyl)phthalazine | HCID 22741951 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 7-Acetamino-1-(3-chloroanilino)-4-(4-pyridylmethyl)phthalazine hydrochloride | HCID 22742013 | — |
反応手順
By analogy with Example 25, 300 mg (0.96 mmol) 7-acetamino-1-chloro-4-(4-pyridylmethyl)-phthalazine is reacted in 3.9 ml 1-butanol with 302 μl (2.88 mmol) 3-chloroaniline. Suspension of the raw product in 1 ml boiling ethanol and filtration lead to the title compound: HPLC: tRet(Grad5-40)=11.3; FAB MS (M+H)+=404.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06710047B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-9e2ce66826cc481a866d58559b881a2a |
| 出典メモ | uspto-grants-2004_03 |