3-Chloroaniline → 7-Acetamino-1-(3-chloroanilino)-4-(4-pyridylmethyl)phthalazine hydrochloride

HRID 49876

反応式

HRID 49876 の反応式
[NH:1]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([CH2:16][C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)=[N:10][N:11]=[C:12]2[Cl:15])=[CH:7][CH:6]=1)[C:2]([CH3:4])=[O:3].[Cl:23][C:24]1[CH:25]=[C:26]([CH:28]=[CH:29][CH:30]=1)[NH2:27]>C(O)CCC>[ClH:15].[NH:1]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([CH2:16][C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)=[N:10][N:11]=[C:12]2[NH:27][C:26]2[CH:28]=[CH:29][CH:30]=[C:24]([Cl:23])[CH:25]=2)=[CH:7][CH:6]=1)[C:2]([CH3:4])=[O:3]

参加物

4

反応物 2

HCID 79323-ChloroanilineHCID 227419517-Acetamino-1-chloro-4-(4-pyridylmethyl)phthalazine

生成物 1

HCID 227420137-Acetamino-1-(3-chloroanilino)-4-(4-pyridylmethyl)phthalazine hydrochloride

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

By analogy with Example 25, 300 mg (0.96 mmol) 7-acetamino-1-chloro-4-(4-pyridylmethyl)-phthalazine is reacted in 3.9 ml 1-butanol with 302 μl (2.88 mmol) 3-chloroaniline. Suspension of the raw product in 1 ml boiling ethanol and filtration lead to the title compound: HPLC: tRet(Grad5-40)=11.3; FAB MS (M+H)+=404.

後処理

  1. filtrationethanol and filtration lead to the title compound

出典と根拠

ORDレコード
ord-9e2ce66826cc481a866d58559b881a2a
出典データセット
uspto-grants-2004_03
特許番号
US06710047B2

関連ノート

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