HCID 69486856、化合物 → HCID 22317612、化合物

反応式

C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([Cl:15])=[CH:10][C:9]=1[NH2:16])(C)(C)C.C(O[C:23](=[O:44])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]2[CH:38]=[C:37]([NH:39][CH2:40][CH2:41][O:42][CH3:43])[N:36]=[CH:35][N:34]=2)[CH:28]=1)=O)(C)(C)C>>[Cl:15][C:11]1[C:12]([CH3:14])=[CH:13][C:8]2[N:7]=[C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([C:33]4[CH:38]=[C:37]([NH:39][CH2:40][CH2:41][O:42][CH3:43])[N:36]=[CH:35][N:34]=4)[CH:28]=3)[CH2:24][C:23](=[O:44])[NH:16][C:9]=2[CH:10]=1

参加物

反応物 2

HCID 69486856HCID 69486856、化合物

HCID 69486983tert-Butyl (2-amino-4-chloro-5-methylphenyl)carbamate

生成物 1

HCID 22317612HCID 22317612、化合物

実験手順

The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic acid tert-butyl ester (Example J22) (128 mg, 0.5 mmol) and 3-{3-[6-(2-methoxy-ethylamino)-pyrimidin-4-yl]-phenyl}-3-oxo-propionic acid tert-butyl ester (Example K56) (204 mg, 0.55 mmol) according to the general procedure M and subsequent treatment of the crude product according to the general procedure N. Obtained as a light yellow solid (118 mg).

出典と根拠

ORDレコード: ord-fc2b911dad8f42a9a1f8ea845c9a6049
出典データセット: uspto-grants-2005_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06949542B2

反応ノート

読み込み中…