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(RS)-N-benzyl-N-methyl-2-phenylglycinamide → (S)-N-benzyl-N-methyl-2-phenylglycinamide di(o-toluoyl)-L-tartrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (RS)-N-benzyl-N-methyl-2-phenylglycinamide | HCID 22262712 | — |
| 反応物 | Ditoluoyl-l-tartaric acid | HCID 129746773 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (S)-N-benzyl-N-methyl-2-phenylglycinamide di(o-toluoyl)-L-tartrate | HCID 131724412 | — |
反応手順
In a preferred embodiment, (RS)-N-benzyl-N-methyl-2-phenylglycinamide is treated with di(o-toluoyl)-L-tartaric acid in methanol at 20° C. The precipitated salt is filtered and washed with methanol, then dried providing (S)-N-benzyl-N-methyl-2-phenylglycinamide di(o-toluoyl)-L-tartrate with 92.7% d.e. (chiral HPLC). This material is reslurried in hot methanol, filtered, washed and dried to providing (S)-N-benzyl-N-methyl-2-phenylglycinamide di(o-toluoyl)-L-tartrate with 99% d.e. (37% overall yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06949572B2 |
| 出典データセット | uspto-grants-2005_09 |
| ORD ID | ord-2feec55e2be34430a59bf887e2c68f1c |
| 出典メモ | uspto-grants-2005_09 |