反応式
C(=O)(OCC([C:7]([CH3:10])([CH3:9])[CH3:8])Br)N.[OH:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=1[I:21])[C:16]#[N:17].[C:22](=[O:25])([O-])[O-:23].[K+].[K+].C(O[CH2:32][CH3:33])(=O)C.C[N:35](C)C=O>>[C:7]([O:23][C:22]([NH:35][CH2:32][CH2:33][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=1[I:21])[C:16]#[N:17])=[O:25])([CH3:8])([CH3:9])[CH3:10]参加物
6
反応条件
- 温度
- 75 °C
実験手順
18.5 g (82.6 mmol) of t-butyl(2-bromoethyl) carbamate was dissolved in 200 ml of dimethylformamide (DMF). 10.1 g (41.3 mmol) of 3-hydroxy-4-iodobenzonitrile and 5.7 g (41.3 mmol) of potassium carbonate were added to the obtained solution, and they were stirred at 75° C. for 3 hours. After the treatment with ethyl acetate as the extracting solvent by an ordinary method, the title compound was obtained.
出典と根拠
- ORDレコード
- ord-f057bf6c92d5447e941c0f2a6d468359
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06710056B2
関連ノート
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