Hydrochloric Acid → 4-(2-fluoro-phenyl)-2-morpholin-4-yl-pyrimidine-5-carboxylic acid benzyl-isopropyl-amide HCl salt
反応式
[CH2:1]([N:8]([CH:30]([CH3:32])[CH3:31])[C:9]([C:11]1[C:12]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[F:29])=[N:13][C:14]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[N:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:33]>CCOCC>[ClH:33].[CH2:1]([N:8]([CH:30]([CH3:32])[CH3:31])[C:9]([C:11]1[C:12]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[F:29])=[N:13][C:14]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[N:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
To a solution of 4-(2-fluoro-phenyl)-2-morpholin-4-yl-pyrimidine-5-carboxylic acid benzyl-isopropyl-amide in Et2O (20 mL) was added IN HCl in Et2O (15 mL, 15 mmol). The resulting slurry was stirred vigorously for 1 hour. The solids were filtered off, washed with Et2O (2×20 mL), and dried in vacuo (0.01 mbar) overnight to yield 4-(2-fluoro-phenyl)-2-morpholin-4-yl-pyrimidine-5-carboxylic acid benzyl-isopropyl-amide HCl salt (5.70 g, 12.10 mmol, 93%).