Triethylamine → 2-(1H-Pyrrol-2-yl)-4H-1,3-benzothiazine-4-one
反応式
[C:1]([O:10]C)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[SH:4].[NH:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]#[N:18].C(N(CC)CC)C>C1(C)C=CC=CC=1>[NH:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]1[S:4][C:3]2[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=2[C:1](=[O:10])[N:18]=1参加物
5
実験手順
A mixture of methyl thiosalicylate (2.00 g, 11.8 mmol), pyrrole-2-carbonitrile (1.10 g, 11.9 mmol), triethylamine (2.00 ml, 14.3 mmol) and toluene (4.0 ml) was refluxed for 15 hrs as described in Example 1. After cooling, the precipitated crystals were collected by filtration and recrystallized from hexane-ethanol to give the titled compound (1.90 g, 73%).
後処理
- temperaturewas refluxed for 15 hrs
- temperatureAfter cooling
- filtrationthe precipitated crystals were collected by filtration
- customrecrystallized from hexane-ethanol
出典と根拠
- ORDレコード
- ord-60d27daf1fe24dcda370de0b064998bc
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07767665B2
反応ノート
読み込み中…