Hydrochloric Acid → 1-(Pyridin-4-yl)piperidine-3-carboxylic acid hydrochloride

HRID 49942ノート

反応式

HRID 49942 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH2:10][CH:9]([C:13]([O:15]CC)=[O:14])[CH2:8]2)=[CH:3][CH:2]=1.[ClH:18]>O1CCOCC1>[ClH:18].[N:1]1[CH:2]=[CH:3][C:4]([N:7]2[CH2:12][CH2:11][CH2:10][CH:9]([C:13]([OH:15])=[O:14])[CH2:8]2)=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 12895985Ethyl 1-(pyridin-4-yl)piperidine-3-carboxylate

生成物 1

HCID 691427091-(Pyridin-4-yl)piperidine-3-carboxylic acid hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 1.8 g of ethyl 1-(4-pyridyl)-piperidine-3-carboxylate, 50 ml of dioxane and 20 ml of 1 M hydrochloric acid was heated under reflux for 5 hours. The solvent was evaporated, and the residue was washed with ethyl acetate to obtain the title compound.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hours
  3. customThe solvent was evaporated
  4. washthe residue was washed with ethyl acetate

出典と根拠

ORDレコード
ord-8e3b448397e646fe82b0b737be53b5bf
出典データセット
uspto-grants-2004_03
特許番号
US06710056B2

反応ノート

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