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Hydrochloric Acid → 2-Fluoro-5-(trifluoromethyl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 4-Fluoro-3-nitrobenzotrifluoride | HCID 67778 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 触媒 | Iron | HCID 23925 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-Fluoro-5-(trifluoromethyl)aniline | HCID 136349 | 82% |
反応手順
Twenty grams of 3-nitro-4-fluorobenzotrifluoride was dissolved in 50 ml of methanol. An iron powder (16 g) was added and concentrated hydrochloric acid was added dropwise with stirring. The reaction mixture was stirred overnight, followed by addition of sodium bicarbonate for neutralization. Then diethyl ether was added, and the insolubles were filtered off with cerite. The ether phase was separated, dried and concentrated under reduced pressure, giving 14 g of the contemplated product (yield 82%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06710062B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-67f0e5b6c7a5411682cf7addfc7c992c |
| 出典メモ | uspto-grants-2004_03 |