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Tetrahydrofuran → 2-Cyano-6-methylthiopyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 6-Chloropyrazine-2-carbonitrile | HCID 81303 | — |
| 反応物 | Sodium methanethiolate | HCID 4378561 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Cyano-6-methylthiopyrazine | HCID 22939281 | 83% |
反応手順
A mixture of 2-chloro-6-cyanopyrazine (1.40 g, 10.0 mmol), sodium thiomethoxide (0.78 g, 11.0 mmol) and THF (100 ml) was refluxed for 2 hrs. The reaction mixture was combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over magnesium sulfate. The solvent was evaporated to give the titled compound (1.25 g, 83%) as pale yellow crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07767665B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-10c916b4118a4d4fb5af290e415fd27f |
| 出典メモ | uspto-grants-2010_08 |