Dimethylformamide → tert-Butyl [methyl(6-cyano-2-pyrazinyl)amino]acetate

HRID 499557

反応式

HRID 499557 の反応式
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]#[N:9])[N:3]=1.Cl.[C:11]([O:15][C:16](=[O:20])[CH2:17][NH:18][CH3:19])([CH3:14])([CH3:13])[CH3:12].C(N(CC)CC)C.CN(C=O)C>O.C(OCC)(=O)C>[CH3:19][N:18]([CH2:17][C:16]([O:15][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:20])[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]#[N:9])[N:3]=1

参加物

7

反応物 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 813036-Chloropyrazine-2-carbonitrileHCID 11252350Sarcosine t-butyl ester hydrochloride

生成物 1

HCID 70859746tert-Butyl [methyl(6-cyano-2-pyrazinyl)amino]acetate収率 27%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

2-Chloro-6-cyanopyrazine (2.09 g, 15.0 mmol), sarcosine tert-butyl ester hydrochloride salt (2.72 g, 15.0 mmol) and triethylamine (2.38 ml, 17.0 mmol) were added to DMF (30 ml), and the mixture was stirred at room temperature for 18 hrs. The reaction mixture was combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the titled compound (1.00 g, 27%) as pale yellow crystals.

後処理

  1. washThe organic layer was washed with saturated brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-19e99a7d51ce44e6adc06719f872c43a
出典データセット
uspto-grants-2010_08
特許番号
US07767665B2

関連ノート

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