1-Propene, 1-methoxy- → HCID 12186155、化合物

HRID 499700ノート

反応式

HRID 499700 の反応式
[CH2:1]([O:8][C:9](=[O:23])[CH2:10][CH2:11][C@H:12]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:13][OH:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[C:25]1(C)[CH:30]=CC(S(O)(=O)=O)=C[CH:26]=1.COC=CC>C(Cl)Cl>[C:19]([O:18][C:16]([N:15]1[C@@H:12]([CH2:11][CH2:10][C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:23])[CH2:13][O:14][C:25]1([CH3:30])[CH3:26])=[O:17])([CH3:20])([CH3:22])[CH3:21]

参加物

5

反応物 3

HCID 1112901-Propene, 1-methoxy-HCID 521998p-Toluenesulfonic acid monohydrateHCID 11198087HCID 11198087、化合物

生成物 1

HCID 12186155HCID 12186155、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution of 52.46 g of 4(S)-tert-butoxycarbonylamino-5-hydroxy-pentanoic acid benzyl ester [9069-62-8] and 895 mg of p-toluenesulfonic acid hydrate in 125 ml of methylene chloride at 0° C. under argon are added 31 ml of methoxypropene over 15 minutes. The mixture is stirred at 0° C. for 3 hours, then at room temperature for 9 hours. The mixture is washed with saturated sodium bicarbonate solution and dried over sodium sulphate, filtered and concentrated. The title compound is obtained as a yellow oil from the residue by means of flash chromatography (SiO2 60 F). Rf=0.32 (1:3 EtOAc-heptane); Rt=5.32 (gradient I).

後処理

  1. waitat room temperature for 9 hours
  2. washThe mixture is washed with saturated sodium bicarbonate solution
  3. dry with materialdried over sodium sulphate
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-c86306703f284f3480d3cff5851b04ce
出典データセット
uspto-grants-2010_08
特許番号
US07767690B2

反応ノート

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