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Diethyl Ether → N-{[3-(4-{[(Aminocarbonyl)amino]methyl}phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}-5-chloro-2-thiophenecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Trimethylsilyl isocyanate | HCID 70696 | — |
| 反応物 | N-({3-[4-(aminomethyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)-5-chloro-2-thiophenecarboxamide | HCID 21070786 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-{[3-(4-{[(Aminocarbonyl)amino]methyl}phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}-5-chloro-2-thiophenecarboxamide | HCID 21070785 | — |
反応手順
0.19 ml (0.82 mmol) of trimethylsilyl isocyanate is added dropwise to a mixture of 30 mg (0.082 mmol) of N-({3-[4-(aminomethyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)-5-chloro-2-thiophenecarboxamide (from Example 148) in 1.0 ml of dichloromethane at room temperature. The mixture is stirred overnight before, after addition of ether, the product is obtained by filtration. Yield: 21.1 mg (52% of theory),
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07767702B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-46d77ea2cc4243b69a7caa99311da658 |
| 出典メモ | uspto-grants-2010_08 |