Potassium Carbonate → Tert-butyl (3r)-1-{4-[(5s)-5-({[(5-chloro-2-thienyl)carbonyl]amino}methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-2-oxo-3-pyrrolidinylcarbamate

HRID 499745

反応式

HRID 499745 の反応式
[C:1]([O:5][C:6]([NH:8][C@@H:9]([C:14]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]2[CH2:27][C@H:26]([CH2:28][NH:29][C:30]([C:32]3[S:33][C:34]([Cl:37])=[CH:35][CH:36]=3)=[O:31])[O:25][C:24]2=[O:38])=[CH:19][CH:18]=1)=[O:15])[CH2:10][CH2:11]SC)=[O:7])([CH3:4])([CH3:3])[CH3:2].[I-].C[S+](C)C.C(=O)([O-])[O-].[K+].[K+]>CS(C)=O>[Cl:37][C:34]1[S:33][C:32]([C:30]([NH:29][CH2:28][C@@H:26]2[O:25][C:24](=[O:38])[N:23]([C:20]3[CH:21]=[CH:22][C:17]([N:16]4[CH2:11][CH2:10][C@@H:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:2])[CH3:3])[C:14]4=[O:15])=[CH:18][CH:19]=3)[CH2:27]2)=[O:31])=[CH:36][CH:35]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 75127Trimethylsulfonium iodideHCID 58777723N2-(tert-butoxycarbonyl)-N1-{4-[(5S)-5-({[(5-chloro-2-thienyl) carbonyl]amino}methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-D-methioninamide

生成物 1

HCID 57496678Tert-butyl (3r)-1-{4-[(5s)-5-({[(5-chloro-2-thienyl)carbonyl]amino}methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-2-oxo-3-pyrrolidinylcarbamate

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
80 °C

実験手順

170 mg (0.292 mmol) of N2-(tert-butoxycarbonyl)-N1-{4-[(5S)-5-({[(5-chloro-2-thienyl)carbonyl]amino}methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-D-methioninamide are dissolved in 2 ml of DMSO, and 178.5 mg (0.875 mmol) of trimethylsulfonium iodide and 60.4 mg (0.437 mmol) of potassium carbonate are added, and the mixture is stirred at 80° C. for 3.5 hours. It is then evaporated under high vacuum, and the residue is washed with ethanol. 99 mg of the target compound remain.

後処理

  1. customIt is then evaporated under high vacuum
  2. washthe residue is washed with ethanol

出典と根拠

ORDレコード
ord-77f0fe652d1746dab48ccfad5d7019c9
出典データセット
uspto-grants-2010_08
特許番号
US07767702B2

関連ノート

読み込み中…