Sodium Bicarbonate → Aliskiren

HRID 500016ノート

反応式

HRID 500016 の反応式
C(OC(=O)[NH:7][C@@H:8]([CH2:26][C@H:27]([CH2:31][C:32]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([O:40][CH2:41][CH2:42][CH2:43][O:44][CH3:45])[CH:33]=1)[CH:28]([CH3:30])[CH3:29])[C@@H:9]([OH:25])[CH2:10][C@H:11]([C:15](=[O:24])[NH:16][CH2:17][C:18]([C:21](=[O:23])[NH2:22])([CH3:20])[CH3:19])[CH:12]([CH3:14])[CH3:13])(C)(C)C.C(=O)(O)[O-].[Na+]>Cl.O1CCOCC1>[NH2:7][C@@H:8]([CH2:26][C@H:27]([CH2:31][C:32]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([O:40][CH2:41][CH2:42][CH2:43][O:44][CH3:45])[CH:33]=1)[CH:28]([CH3:29])[CH3:30])[C@@H:9]([OH:25])[CH2:10][C@@H:11]([CH:12]([CH3:13])[CH3:14])[C:15]([NH:16][CH2:17][C:18]([C:21](=[O:23])[NH2:22])([CH3:20])[CH3:19])=[O:24]

参加物

5

反応物 2

HCID 516892Sodium BicarbonateHCID 53348234tert-Butyl [(3S,5S,6S,8S)-8-[(3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl]-6-hydroxy-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-2,9-dimethyldecan-5-yl]carbamate

生成物 1

HCID 5493444Aliskiren

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 312751,4-Dioxane溶媒

実験手順

Product 13 is dissolved in a mixture of 4.0M hydrochloric acid in dioxane. The solution is stirred for 24 hours at room temperature and neutralized with solid sodium bicarbonate. The suspension is filtered and the solvent removed in vacuum to give the product as a foam (for characterization see e.g. EP 0 678 503, Example 137).

後処理

  1. filtrationThe suspension is filtered
  2. customthe solvent removed in vacuum

出典と根拠

ORDレコード
ord-ab4596c6eae7472bb5bd1d8be44d3a6c
出典データセット
uspto-grants-2010_08
特許番号
US07767831B2

反応ノート

読み込み中…