関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,4-Butane sultone | HCID 15411 | — |
| 反応物 | Sulfolane | HCID 31347 | — |
| 反応物 | 2,3-Dimethyl-3-(4-sulfobutyl)-3H-indole-5-sulfonic acid | HCID 59366226 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2,3-Dimethyl-1,3-bis(4-sulfobutyl)-5-sulfo-3H-indole | HCID 86646192 | 86.8% |
反応手順
To 2,3-dimethyl-3-(4-sulfobutyl)-5-sulfo-3H-indole (10 g) was added butane sultone (30 g) and the mixture heated to 140° C. overnight. On cooling to room temperature, sulfolan (20 ml) was added and the mixture poured into diethyl ether (500 ml). The resultant precipitate was removed by filtration and dried to give the desired product (12 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07767829B2 |
|---|
| 出典データセット | uspto-grants-2010_08 |
|---|
| ORD ID | ord-967fe06e8ce64cbea94cfa6f6fa5c726 |
|---|
| 出典メモ | uspto-grants-2010_08 |
|---|
