1,4-Butane sultone → 2,3-Dimethyl-1,3-bis(4-sulfobutyl)-5-sulfo-3H-indole

HRID 500099

反応式

HRID 500099 の反応式
[CH3:1][C:2]1[C:10]([CH3:19])([CH2:11][CH2:12][CH2:13][CH2:14][S:15]([OH:18])(=[O:17])=[O:16])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([S:20]([OH:23])(=[O:22])=[O:21])[CH:8]=2)[N:3]=1.[CH2:24]1[S:29](=[O:31])(=[O:30])[O:28][CH2:27][CH2:26][CH2:25]1.S1(CCCC1)(=O)=O>C(OCC)C>[CH3:1][CH:2]1[C:10]([CH3:19])([CH2:11][CH2:12][CH2:13][CH2:14][S:15]([OH:18])(=[O:16])=[O:17])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([S:20]([OH:23])(=[O:21])=[O:22])[CH:8]=2)[N:3]1[CH2:27][CH2:26][CH2:25][CH2:24][S:29]([OH:31])(=[O:30])=[O:28]

参加物

5

反応物 3

HCID 154111,4-Butane sultoneHCID 31347SulfolaneHCID 593662262,3-Dimethyl-3-(4-sulfobutyl)-3H-indole-5-sulfonic acid

生成物 1

HCID 866461922,3-Dimethyl-1,3-bis(4-sulfobutyl)-5-sulfo-3H-indole収率 86.8%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
140 °C

実験手順

To 2,3-dimethyl-3-(4-sulfobutyl)-5-sulfo-3H-indole (10 g) was added butane sultone (30 g) and the mixture heated to 140° C. overnight. On cooling to room temperature, sulfolan (20 ml) was added and the mixture poured into diethyl ether (500 ml). The resultant precipitate was removed by filtration and dried to give the desired product (12 g).

後処理

  1. temperatureOn cooling to room temperature
  2. customThe resultant precipitate was removed by filtration
  3. customdried

出典と根拠

ORDレコード
ord-967fe06e8ce64cbea94cfa6f6fa5c726
出典データセット
uspto-grants-2010_08
特許番号
US07767829B2

関連ノート

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