2-Chloro-3-(4-methoxyphenyl)propanal → 2-(4-Fluorophenyl)-7-(4-methoxybenzyl)imidazo[1,2-b][1,2,4]triazine

HRID 500109ノート

反応式

HRID 500109 の反応式
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][CH:10]=2)=[CH:5][CH:4]=1.Cl[CH:17]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=1)[CH:18]=O>C(O)(CC)(C)C>[F:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[N:11][C:12]3[N:13]([C:17]([CH2:20][C:21]4[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=4)=[CH:18][N:15]=3)[N:14]=2)=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 121027562-Chloro-3-(4-methoxyphenyl)propanalHCID 672240866-(4-Fluorophenyl)-1,2,4-triazin-3-amine hydrochloride

生成物 1

HCID 248018432-(4-Fluorophenyl)-7-(4-methoxybenzyl)imidazo[1,2-b][1,2,4]triazine

試薬・触媒・溶媒 1

HCID 64052-Methyl-2-butanol溶媒

反応条件

温度
130 °C

実験手順

A mixture of 6-(4-fluorophenyl)-1,2,4-triazin-3-amine hydrochloride (50 mg, 0.2 mmol) and 2-chloro-3-(4-methoxyphenyl)propanal (48 mg, 0.24 mmol) in tert-amyl alcohol (1 mL) was heated at 130° C. for 4 h. After cooling, the mixture was purified by preparative HPLC to afford the desired product. (7.1 mg) LCMS: (M+H)=335.1.

後処理

  1. temperatureAfter cooling
  2. customthe mixture was purified by preparative HPLC

出典と根拠

ORDレコード
ord-c8450fcda9374181b026ca5f8d1a60c5
出典データセット
uspto-grants-2010_08
特許番号
US07767675B2

反応ノート

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