Ammonia → 5-(4-Fluorophenyl)pyrimidin-2-amine

HRID 500113ノート

反応式

HRID 500113 の反応式
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:4][N:3]=1.[NH3:15]>CO>[F:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[CH:4]=[N:3][C:2]([NH2:15])=[N:7][CH:6]=2)=[CH:9][CH:10]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 203333512-Chloro-5-(4-fluorophenyl)pyrimidine

生成物 1

HCID 129466475-(4-Fluorophenyl)pyrimidin-2-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-Chloro-5-(4-fluorophenyl)pyrimidine (376 mg) in 7M of ammonia in methanol (10 mL) in a sealed tube was heated at 50° C. overnight. After concentration, the product was obtained (360 g) which was used in the next reaction step without further purification. LCMS: (M+H)=190.1.

後処理

  1. concentrationAfter concentration
  2. customthe product was obtained (360 g) which
  3. customwas used in the next reaction step without further purification

出典と根拠

ORDレコード
ord-fcebbcab1722486da4b0340766b1e6f9
出典データセット
uspto-grants-2010_08
特許番号
US07767675B2

反応ノート

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