2-Chloro-3-(4-methoxyphenyl)propanal → 6-(4-Fluorophenyl)-3-(4-methoxybenzyl)imidazo[1,2-a]pyrimidine

HRID 500114ノート

反応式

HRID 500114 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][C:11]([NH2:14])=[N:12][CH:13]=2)=[CH:4][CH:3]=1.Cl[CH:16]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=1)[CH:17]=O>C(O)(CC)(C)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[N:12][C:11]3[N:10]([C:16]([CH2:19][C:20]4[CH:21]=[CH:22][C:23]([O:26][CH3:27])=[CH:24][CH:25]=4)=[CH:17][N:14]=3)[CH:9]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 121027562-Chloro-3-(4-methoxyphenyl)propanalHCID 129466475-(4-Fluorophenyl)pyrimidin-2-amine

生成物 1

HCID 251455126-(4-Fluorophenyl)-3-(4-methoxybenzyl)imidazo[1,2-a]pyrimidine

試薬・触媒・溶媒 1

HCID 64052-Methyl-2-butanol溶媒

反応条件

温度
130 °C

実験手順

A mixture of 5-(4-fluorophenyl)pyrimidin-2-amine (50 mg, 0.3 mmol), 2-chloro-3-(4-methoxyphenyl)propanal (52 mg, 0.26 mmol) in tert-amyl alcohol (1.0 mL) in a sealed reaction vial was heated at 130° C. for 3 hours. After cooling, the mixture was purified by preparative HPLC to afford the desired product. LCMS: (M+H)=334.0.

後処理

  1. customin a sealed reaction
  2. temperatureAfter cooling
  3. customthe mixture was purified by preparative HPLC

出典と根拠

ORDレコード
ord-cc7561f2aeec4985a6270737d3ff10a8
出典データセット
uspto-grants-2010_08
特許番号
US07767675B2

反応ノート

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