4-Sulfanylbutan-1-ol → 5-[2-[(4-hydroxybutyl)thio]-2-(3-thienyl)ethyl]-2-methyl-2-phenylfuran-3(2H)-one

HRID 50021

反応式

HRID 50021 の反応式
[CH3:1][C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:6](=[O:7])[CH:5]=[C:4](/[CH:8]=[CH:9]/[C:10]2[CH:14]=[CH:13][S:12][CH:11]=2)[O:3]1.[SH:21][CH2:22][CH2:23][CH2:24][CH2:25][OH:26]>>[OH:26][CH2:25][CH2:24][CH2:23][CH2:22][S:21][CH:9]([C:10]1[CH:14]=[CH:13][S:12][CH:11]=1)[CH2:8][C:4]1[O:3][C:2]([CH3:1])([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:6](=[O:7])[CH:5]=1

参加物

3

反応物 2

HCID 5482614-Sulfanylbutan-1-olHCID 11300541(E)-2-methyl-2-phenyl-5-[2-(3-thienyl)ethenyl]-3(2H)-furanone

生成物 1

HCID 101108545-[2-[(4-hydroxybutyl)thio]-2-(3-thienyl)ethyl]-2-methyl-2-phenylfuran-3(2H)-one

実験手順

According to the procedure of Method A, Example 1, (E)-2-methyl-2-phenyl-5-[2-(3-thienyl)ethenyl]-3(2H)-furanone was reacted with 4-mercapto-1-butanol to provide 5-[2-[(4-hydroxybutyl)thio]-2-(3-thienyl)ethyl]-2-methyl-2-phenylfuran-3(2H)-one: 1H NMR (CDCl3) δ1.52-1.70 (broad s with fine structure, ˜5H) and 1.65 and 1.67 (singlets, 3H), 2.41 (m, 2H), 3.08-3.24 (m, 2H), 3.60 (m, 2H), 4.40 (m, 1H), 5.37 and 5.39 (singlets, 1H), 7.05-7.16 (m, 2H), 7.25-7.40 (m, 6H); MS (HR-EI) m/z 388.1161 (M+ calcd. for C21H24O3S2 388.1167).

出典と根拠

ORDレコード
ord-bc15f04229604abf867b17c94140bdee
出典データセット
uspto-grants-2004_03
特許番号
US06710078B2

関連ノート

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