1,2-Ethanedithiol → 5-[2-[(2-mercaptoethyl)thio]-2-(3-thienyl)ethyl]-2-methyl-2-phenylfuran-3(2H)-one

HRID 50024

反応式

HRID 50024 の反応式
[CH3:1][C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:6](=[O:7])[CH:5]=[C:4](/[CH:8]=[CH:9]/[C:10]2[CH:14]=[CH:13][S:12][CH:11]=2)[O:3]1.[CH2:21]([SH:24])[CH2:22][SH:23]>>[SH:23][CH2:22][CH2:21][S:24][CH:9]([C:10]1[CH:14]=[CH:13][S:12][CH:11]=1)[CH2:8][C:4]1[O:3][C:2]([CH3:1])([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:6](=[O:7])[CH:5]=1

参加物

3

反応物 2

HCID 109021,2-EthanedithiolHCID 11300541(E)-2-methyl-2-phenyl-5-[2-(3-thienyl)ethenyl]-3(2H)-furanone

生成物 1

HCID 101775745-[2-[(2-mercaptoethyl)thio]-2-(3-thienyl)ethyl]-2-methyl-2-phenylfuran-3(2H)-one

実験手順

According to the procedure of Method A, Example 1, (E)-2-methyl-2-phenyl-5-[2-(3-thienyl)ethenyl]-3(2H)-furanone was reacted with 1,2-ethanedithiol to provide 5-[2-[(2-mercaptoethyl)thio]-2-(3-thienyl)ethyl]-2-methyl-2-phenylfuran-3(2H)-one: 1H NMR (CDCl3) δ1.63 (m, 1H) and overlapping 1.65 and 1.68 (singlets, 3H), 2.47-2.80 (m, 4H), 3.07-3.25 (m, 2H), 4.47 (m, 1H), 5.37 and 5.39 (singlets, 1H), 7.05-7.18 (m, 2H), 7.25-7.45 (m, 6H); MS (HR-EI) m/z 376.0605 (M+ calcd. for C19H20O2S3 376.0626).

出典と根拠

ORDレコード
ord-bae6df5a9a54424aa1aa70b4d77b051d
出典データセット
uspto-grants-2004_03
特許番号
US06710078B2

関連ノート

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