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HRID 500264作成日：2026年10月26日
Lamotrigine → 2-(2,3-Dichlorophenyl)-7-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-b][1,2,4]triazin-3-amine
https://huagongshe.com/reaction/500264
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Lamotrigine | HCID 3878 | — |
| 反応物 | Chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde | HCID 86621504 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(2,3-Dichlorophenyl)-7-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-b][1,2,4]triazin-3-amine | HCID 59420986 | 35.3% |
反応手順
A mixture of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine (19 mg, 0.076 mmol) and chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde (22 mg, 0.091 mmol) in ethanol (0.50 mL) was stirred at 105° C. overnight. The reaction mixture was purified by RP-HPLC (pH 10) to afford the desired product (12 mg, 35%). LCMS: (M+H)=447.3/449.2/451.2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07767675B2 |
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| 出典データセット | uspto-grants-2010_08 |
|---|
| ORD ID | ord-788f1ae73f394baf9e0803381a02361a |
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| 出典メモ | uspto-grants-2010_08 |
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