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HRID 50029作成日：2026年10月25日

2-Mercaptoethanol → 2-(4-fluorophenyl)-5-[2-[(2-hydroxyethyl)thio]-2-(3-thienyl)ethyl]-2-methylfuran-3(2H)-one

https://huagongshe.com/reaction/50029

反応式

関与物質

役割名称HCID仕込み量
反応物2-MercaptoethanolHCID 1567—
反応物(E)-2-(4-fluorophenyl)-2-methyl-5-[2-(3-thienyl)ethenyl]-3(2H)-furanoneHCID 15086707—
生成物2-(4-fluorophenyl)-5-[2-[(2-hydroxyethyl)thio]-2-(3-thienyl)ethyl]-2-methylfuran-3(2H)-oneHCID 10271015—

反応手順

Following the procedure of Method C, Example 1, (E)-2-(4-fluorophenyl)-2-methyl-5-[2-(3-thienyl)ethenyl]-3(2H)-furanone was reacted with 2-mercapto-1-ethanol to provide 2-(4-fluorophenyl)-5-[2-[(2-hydroxyethyl)thio]-2-(3-thienyl)ethyl]-2-methylfuran-3(2H)-one: 1H NMR (DMSO-d6) δ1.53 and 1.56 (singlets, 3H), 4.39 (m, 1H), 5.56 (overlapped singlets, 1H), 7.08-7.35 (m, 5H), 7.43-7.60 (m, 2H); MS (HR-Cl) m/z 379.0832 (M+H calcd. for C19H20FO3S2 379.0837)

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06710078B2
出典データセットuspto-grants-2004_03
ORD IDord-00661aa2a7f64a518d0e279b3b0fc27d
出典メモuspto-grants-2004_03