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HRID 500385作成日：2026年10月26日

Benzoyl chloride → 18-Benzoyloxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo-[14.3.0.04,6]-nonadec-7-ene

https://huagongshe.com/reaction/500385

反応式

関与物質

役割名称HCID仕込み量
反応物Benzoyl chlorideHCID 7412—
反応物18-Hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo[14.3.0.04,6]-nonadec-7-eneHCID 72260127—
生成物18-Benzoyloxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo-[14.3.0.04,6]-nonadec-7-eneHCID 7244537448%

反応手順

Prepared by way of method I using 18-hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo[14.3.0.04,6]-nonadec-7-ene (100 mg, 0.175 mmol) and benzoyl chloride (61 μL, 0.53 mmol). The final trituration (diethyl ether/hexane) and filtration gave 56 mg (48%) of 18-benzoyloxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo-[14.3.0.04,6]-nonadec-7-ene as a white powder: 99.0% pure (HPLC), MS m/z 673 (M−H)−, HRMS: calcd. 675.2700 and found 675.2709 (M+H)+, mp 135-137° C.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07772183B2
出典データセットuspto-grants-2010_08
ORD IDord-57aae7c1698141a2984a84bc173924e1
出典メモuspto-grants-2010_08