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HRID 500408作成日：2026年10月26日

4-Phenoxyphenyl isocyanate → 18-(4-Phenoxyphenylaminocabonyloxy)-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo-[14.3.0.04,6]-nonadec-7-ene

https://huagongshe.com/reaction/500408

反応式

関与物質

役割名称HCID仕込み量
反応物4-Phenoxyphenyl isocyanateHCID 2734896—
反応物18-Hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo[14.3.0.04,6]-nonadec-7-eneHCID 72260127—
生成物18-(4-Phenoxyphenylaminocabonyloxy)-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo-[14.3.0.04,6]-nonadec-7-eneHCID 7244537338%

反応手順

Prepared by way of method III using 18-hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo[14.3.0.04,6]-nonadec-7-ene (100 mg, 0.175 mmol) and 4-phenoxyphenyl isocyanate (111 mg, 0.53 mmol). The final trituration (diethyl ether/hexane) and filtration gave 52 mg (38%) of 18-(4-phenoxyphenylaminocabonyloxy)-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo-[14.3.0.04,6]-nonadec-7-ene as a white powder: 98.0% pure (HPLC), MS m/z 780 (M−H)−, HRMS: calcd. 799.3337 and found 799.3316 (M+NH4)+, mp 163-165° C.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07772183B2
出典データセットuspto-grants-2010_08
ORD IDord-74e76ff0be5047e683b905637be4b084
出典メモuspto-grants-2010_08