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1,3-Dibromopropane → 4-[(3-Bromopropyl)sulfanyl]benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Dibromopropane | HCID 8001 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Thiobenzonitrile | HCID 585058 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-[(3-Bromopropyl)sulfanyl]benzonitrile | HCID 21867671 | 62.1% |
反応手順
A mixture of 4-cyanothiophenol (20.8 g, 154 mmol), 1,3-dibromopropane (155 g, 0.77 mol) and K2CO3 (21.3 g, 154 mmol) in MeCN (300 mL) was refluxed overnight. Filtration and evaporation of the solvent gave a brown oil that crystallised when treated with EtOH. The crystals were isolated by filtration to give the sub-title compound (24.5 g, 62%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07772229B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-5f68d9d2426e4f13b22d82955b8b4cb2 |
| 出典メモ | uspto-grants-2010_08 |