Sodium Cyanide → 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile

HRID 50053

反応式

HRID 50053 の反応式
[C-:1]#[N:2].[Na+].[CH2:4]([N:11]1[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.Cl.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>O.CO>[CH2:4]([N:11]1[CH2:16][CH2:15][C:14]([C:1]#[N:2])([N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:13][CH2:12]1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

6

反応物 3

HCID 8929Sodium CyanideHCID 192201-Benzyl-4-piperidoneHCID 2723721Piperidine, hydrochloride (1:1)

生成物 1

HCID 27334341'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile収率 95.4%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒2 回

実験手順

A solution of 5.3 g of sodium cyanide in 20 ml of water is added dropwise at RT to a solution of 18.9 g of 1-benzylpiperid-4-one and 12.16 g of piperidine hydrochloride in 25 ml of MeOH and 25 ml of water and the mixture is stirred for 48 hours at RT. The precipitate formed is filtered off, washed with water and dried under vacuum to give 27 g of the expected product.

後処理

  1. customThe precipitate formed
  2. filtrationis filtered off
  3. washwashed with water
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-c1e494c1679f413993b9aba28b5ed289
出典データセット
uspto-grants-2004_03
特許番号
US06710042B2

関連ノート

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