Acetyl chloride → Ethyl 6-oxo-1,6-dihydropyridazine-4-carboxylate

HRID 500536ノート

反応式

HRID 500536 の反応式
[O:1]=[C:2]1[NH:7][N:6]=[CH:5][C:4]([C:8]([OH:10])=[O:9])=[CH:3]1.[C:11](Cl)(=O)[CH3:12]>C(O)C>[CH2:11]([O:9][C:8]([C:4]1[CH:5]=[N:6][NH:7][C:2](=[O:1])[CH:3]=1)=[O:10])[CH3:12]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 123762656-Oxo-1,6-dihydropyridazine-4-carboxylic acid

生成物 1

HCID 12376258Ethyl 6-oxo-1,6-dihydropyridazine-4-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
75 °C

実験手順

The title compound from Example 18.3 (1.0 g, 7.13 mmol) was added to a solution of ethanol (16 mL) and acetyl chloride (4 mL) and the resulting suspension was heated to 75° C. and stirred overnight. The reaction mixture was concentrated, diluted with water and extracted with dichloromethane. The organic phase was dried over sodium sulfate, filtered and concentrated to give the title compound.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. additiondiluted with water
  3. extractionextracted with dichloromethane
  4. dry with materialThe organic phase was dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-3aa33dedd9b04de8a50ea781e5e0a20b
出典データセット
uspto-grants-2010_08
特許番号
US07772235B2

反応ノート

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