Diethyl Ether → 4-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide

HRID 50054ノート

反応式

HRID 50054 の反応式
[Br:1]Br.Cl.[C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)(=[O:6])[CH3:5].CCOCC>C(Cl)Cl>[BrH:1].[Br:1][CH2:5][C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)=[O:6]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 27237674-Acetyl-4-phenylpiperidine hydrochloride

生成物 1

HCID 227417564-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide収率 196.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

8 g of bromine are added rapidly at RT to a suspension of 11.98 g of 4-acetyl-4-phenylpiperidine hydrochloride in 200 ml of DCM and the reaction mixture is left to stand overnight at RT, with stirring. It is diluted by the addition of 200 ml of ether and the precipitate formed is filtered off and washed with ether to give 17.88 g of the expected product after drying under vacuum.

後処理

  1. waitthe reaction mixture is left
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. washwashed with ether

出典と根拠

ORDレコード
ord-dc51313e419d4eada0def3647e473f64
出典データセット
uspto-grants-2004_03
特許番号
US06710042B2

反応ノート

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