化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → 4-Chloro-3-methylbenzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 4-Chloro-3-methylbenzoic acid | HCID 282989 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Chloro-3-methylbenzoyl chloride | HCID 13058375 | — |
反応手順
To a suspension of 52.55 g (0.31 mol) of 4-chloro-3-methyl-benzoic acid in CH2Cl2 (1.2 L) with DMF (1 mL) at 0° C. under N2 with an outlet sparging through 2.5 N sodium hydroxide was added 29.56 mL (0.339 mol) of oxalyl chloride. The mixture was allowed to warm to room temperature over a 3 h period. The reaction mixture was concentrated and taken forward crude.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07772236B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-98621b18a7b345418321c9ad9af11e41 |
| 出典メモ | uspto-grants-2010_08 |