HCID 22024658、化合物 → HCID 22024358、化合物

HRID 501009ノート

反応式

HRID 501009 の反応式
[Br:1][C:2]1[C:3]2[N:4]([CH2:8][CH:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[N:6][CH:7]=1>C1(C)C=CC=CC=1.[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[N:6][CH:7]=1

参加物

4

反応物 1

HCID 22024658HCID 22024658、化合物

生成物 1

HCID 22024358HCID 22024358、化合物収率 43.7%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 1140Toluene溶媒

反応条件

温度
90 °C

実験手順

8-Bromo-2-ethyl-2,3-dihydroimidazo[1,2-c]pyrimidine (3.0 g) was dissolved in toluene (60 mL), then activated manganese (IV) dioxide (3.5 g) was added thereto, and the mixture was heated under stirring at 90° C. for 1 day. Manganese (IV) oxide was filtered off through Celite, and the solvent was evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1:10) to give the title compound (1.3 g) as white crystals.

後処理

  1. temperaturethe mixture was heated
  2. filtrationManganese (IV) oxide was filtered off through Celite
  3. customthe solvent was evaporated
  4. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1:10)

出典と根拠

ORDレコード
ord-837f6f46ed2642a38617b9faa8008681
出典データセット
uspto-grants-2010_08
特許番号
US07772249B2

反応ノート

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