関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 5-Bromopyridine-2-carboxamide | HCID 735151 | — |
| 反応物 | (5-Methoxy-1-benzofuran-2-yl)boronic acid | HCID 22221596 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-(5-Methoxy-benzofuran-2-yl)-pyridine-2-carboxylic acid amide | HCID 25014841 | 28% |
反応手順
5-methoxybenzofuran boronic acid (1.2 mmol), 5-bromopyridine-2-carboxamide (1.0 mmol), Pd(PPh3)2Cl2 (0.024 mmol) and NEt3 (317 μL) were mixed in EtOH (10 mL) in a 20 mL microwave vial. The mixture was stirred at 140° C. for 10 min in a microwave reactor, filtered, and the precipitate was washed with water and EtOAc and dried under vacuum to afford the title compound (75 mg). 1H NMR δ ppm 9.10 (d, 1 H) 8.34 (dd, 1 H) 8.21 (br. s., 1 H) 8.00 (d, 1 H) 7.52-7.72 (m, 3 H) 7.25 (d, 1 H) 7.00 (dd, 1 H) 3.82 (s, 3H); MS m/z 269 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07772256B2 |
|---|
| 出典データセット | uspto-grants-2010_08 |
|---|
| ORD ID | ord-75c556a2aa9943bda142118f08416f36 |
|---|
| 出典メモ | uspto-grants-2010_08 |
|---|
