[7-Benzyl-1-methyl-2,6-dioxo-1,2,6,7-tetrahydropurin-3-yl]methyl 2,2-dimethylpropionate → [1-Methyl-2,6-dioxo-1,2,6,7-tetrahydropurin-3-yl]methyl 2,2-dimethylpropionate

HRID 501368ノート

反応式

HRID 501368 の反応式
[CH3:1][C:2]([CH3:27])([CH3:26])[C:3]([O:5][CH2:6][N:7]1[C:15]2[N:14]=[CH:13][N:12](CC3C=CC=CC=3)[C:11]=2[C:10](=[O:23])[N:9]([CH3:24])[C:8]1=[O:25])=[O:4]>C(O)(=O)C.[C].[Pd]>[CH3:1][C:2]([CH3:27])([CH3:26])[C:3]([O:5][CH2:6][N:7]1[C:15]2[N:14]=[CH:13][NH:12][C:11]=2[C:10](=[O:23])[N:9]([CH3:24])[C:8]1=[O:25])=[O:4]

参加物

4

反応物 1

HCID 23536880[7-Benzyl-1-methyl-2,6-dioxo-1,2,6,7-tetrahydropurin-3-yl]methyl 2,2-dimethylpropionate

生成物 1

HCID 23536866[1-Methyl-2,6-dioxo-1,2,6,7-tetrahydropurin-3-yl]methyl 2,2-dimethylpropionate収率 105.3%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 176Acetic Acid溶媒

実験手順

2.349 g of [7-benzyl-1-methyl-2,6-dioxo-1,2,6,7-tetrahydropurin-3-yl]methyl 2,2-dimethylpropionate was dissolved in 100 ml of acetic acid, and 1 g of 10% palladium carbon was added thereto. The mixture was stirred under a hydrogen atmosphere at room temperature overnight. The reaction mixture was filtered and concentrated to give 1.871 g of the title compound.

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-fb4003cccb7c43ce9b7eb9893bffa1fd
出典データセット
uspto-grants-2010_08
特許番号
US07772226B2

反応ノート

読み込み中…