Potassium Iodide → 4-Chloro-2-iodo-1-nitrobenzene

HRID 50142

反応式

HRID 50142 の反応式
[N+:1]([C:4]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:5]=1N)([O-:3])=[O:2].N([O-])=O.[Na+].[I-:16].[K+]>Cl.O>[N+:1]([C:4]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:5]=1[I:16])([O-:3])=[O:2]

参加物

6

反応物 3

HCID 4875Potassium IodideHCID 742185-Chloro-2-nitroanilineHCID 23668193Sodium Nitrite

生成物 1

HCID 114261004-Chloro-2-iodo-1-nitrobenzene

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 962Water溶媒2 回

実験手順

To a suspension of 2-nitro-5-chloroaniline (5.00 g) in conc. hydrochloric acid (30 ml) under cooling with ice, was added a solution of sodium nitrite (2.10 g) in water (10 ml) dropwise and the mixture was stirred for 30 minutes. Under cooling with ice, to this solution was added a solution of potassium iodide (5.30 g) in water (20 ml) dropwise and the mixture was stirred for 1 hour at room temperature. The solid that appeared was collected by filtration and was dissolved in ethyl acetate and was dried and concentrated to give a crude product of the title compound. It was purified by recrystallization from ethyl acetate-hexane to give the title compound having the following physical data (5.14 g, yellow powder).

後処理

  1. temperatureunder cooling with ice
  2. temperatureUnder cooling with ice, to this solution
  3. stirringthe mixture was stirred for 1 hour at room temperature
  4. filtrationThe solid that appeared was collected by filtration
  5. dissolutionwas dissolved in ethyl acetate
  6. customwas dried
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-e7ff242b5f244e8b8bfce82155179acc
出典データセット
uspto-grants-2004_03
特許番号
US06710205B2

関連ノート

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