Potassium Carbonate → 2-[8-(3-Aminopiperidin-1-yl)-7-(2-butynyl)-2-methoxy-6-oxo-6,7-dihydropurin-1-ylmethyl]benzonitrile hydrochloride

HRID 501420ノート

反応式

HRID 501420 の反応式
[CH2:1]([N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]#[N:23])[C:10]([Cl:24])=[N:9][C:8]=2[N:7]=[C:6]1[N:25]1[CH2:30][CH2:29][CH2:28][CH:27]([NH:31]C(=O)OC(C)(C)C)[CH2:26]1)[C:2]#[C:3][CH3:4].[C:39](=O)([O-])[O-:40].[K+].[K+].Cl.NC1CCCN(C2N(CC#CC)C3C(=O)N(CC4C=CC=CC=4C#N)C(C#N)=NC=3N=2)C1>CO>[ClH:24].[NH2:31][CH:27]1[CH2:28][CH2:29][CH2:30][N:25]([C:6]2[N:5]([CH2:1][C:2]#[C:3][CH3:4])[C:13]3[C:12](=[O:14])[N:11]([CH2:15][C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=4[C:22]#[N:23])[C:10]([O:40][CH3:39])=[N:9][C:8]=3[N:7]=2)[CH2:26]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 230706658-(3-Aminopiperidin-1-yl)-7-(2-butynyl)-1-(2-cyanobenzyl)-6-oxo-6,7-dihydro-1H-purine-2-carbonitrile hydrochlorideHCID 57472737t-butyl [1-[7-(2-butynyl)-2-chloro-1-(2-cyanobenzyl)-6-oxo-6,7-dihydro-1H-purin-8-yl]piperidin-3-yl]carbamate

生成物 1

HCID 230706672-[8-(3-Aminopiperidin-1-yl)-7-(2-butynyl)-2-methoxy-6-oxo-6,7-dihydropurin-1-ylmethyl]benzonitrile hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture consisting of 15 mg of t-butyl [1-[7-(2-butynyl)-2-chloro-1-(2-cyanobenzyl)-6-oxo-6,7-dihydro-1H-purin-8-yl]piperidin-3-yl]carbamate, 20 mg of anhydrous potassium carbonate and 0.2 ml of methanol was stirred for three hours. Subsequent steps were carried out according to the same procedure as used in Examples 242 (f) and (g). Thus, the title compound was synthesized.

出典と根拠

ORDレコード
ord-acf4b13743ba438c871e7e749beecd4c
出典データセット
uspto-grants-2010_08
特許番号
US07772226B2

反応ノート

読み込み中…